ea0006s24 | Steroid replacement | SFE2003
Mah P
, Jenkins R
, Rostami-Hodjegan A
, Newell-Price J
, Doane A
, Ibbotson V
, Tucket G
, Ross R
Background. Adrenal insufficiency requires life long corticosteroid therapy, but optimal dosing of hydrocortisone replacement has not received adequate attention.Chronic over or under treatment predisposes to morbidity and mortality.Objective.To examine the variables determiming hydrocortisone disposition and develop practical protocols for individualised prescribing and monitoring of treatment.Design. Prospective open study.<p...